ABSTRACT
Effect of ranitidine and tiotidine on spermatogenesis in albino rats was determined under local management and climatic conditions. These H2 blocking drugs were administrated to the albino rats in dose of 2.14 and 1.42 mg/kg body weight, twice daily for a period of five weeks. The results revealed that ranitidine caused a significant decrease [P< 0.05] in the number of spermatocytes while tiotidine had no effect on the germ cells in the seminiferous tubules. It is, therefore, likely that ranitidine and tiotidine have antispermatogenic activity
Subject(s)
Animals, Laboratory , Ranitidine/adverse effects , Histamine H2 Antagonists/adverse effects , RatsABSTRACT
Antisecretory effects of cimetidine, ranitidine and tiotidine were studied on histamine-stimulated gastric Secretion in pylorus ligated intact rats at the dose levels. The data obtained showed that the efficacy of these drugs in reducing the volume of gastric juice was in the order of ranitidine> tiotidine> cimetidine. However, their acid reducing capacities were observed to be in the order of ranitidine> cimetidine> tiotidine in the checked doses. Thus, the data suggests that ranitidine is the most effective antiulcer drug of all the three tested H2-bloking agents
Subject(s)
Animals, Laboratory , Ranitidine/pharmacology , Gastric Juice/metabolism , Peptic Ulcer/drug effectsABSTRACT
The effects of cimetidine, ranitidine and tiotidine were studied on spermatogenesis in adult male albino rats after administering these drugs at the dose levels of 5.71 mg/ kg, 2.14 mg/kg and 1.42 mg/kg body weight respectively twice daily for a period of five weeks. The results showed that cimetidine and tiotidine caused a significant decrease [P < 0.05] in the number of spermatocytes. However cimetidine and tiotidine produced a marked decrease [P < 0.05] and [P < 0.001] respectively, in the number of total germ cells in the seminiferous tubules. It is conceivable that ranitidine also possess antispermatogenic activity which was not found out in previous research work